LSD), great care is required to prevent the onset of visual hallucinations and confusion, specifically at higher doses. Also, weight get should be anticipated on account of stimulation from the feeding center by the anticholinergic action of this drug. Longterm treatment with CH ought to be avoided.a migrainepreventive therapy for adult Japanese patients in whom such standard drugs are ineffective or induce undesirable side effects.Competing interests The authors declare that they have no competing interests. Authors’ contribution HO participated in designing the experimental setup, collected and analyzed the information and drafted the manuscript. KI participated in designing the experimental setup, participated in analyzing the information and drafted the manuscript. TY participated in designing the experimental setup, participated in analyzing the data and drafted the manuscript.Buy(DHQD)2AQN KT participated in designing the experimental setup, participated in analyzing the data and drafted the manuscript. YK participated in designing the experimental setup, participated in analyzing the information and drafted the manuscript. All authors read and authorized the final manuscript. Received: 26 April 2013 Accepted: 15 October 2013 Published: 29 October 2013 References Ferrari MD, Roon KI, Lipton RB et al (2001) Oral triptansserotonin 5HT(1B/1D) agonistsin acute migraine therapy: a metaanalysys of 53 trials. Lancet 358:1668Conclusions Currently, antidepressants, betablockers, antiepileptic agents, and calcium antagonists are utilized in Japan to stop frequent, intractable migraine in adults. The results of this study demonstrate that CH is successful asOkuma et al. SpringerPlus 2013, 2:573 http://www.springerplus.com/content/2/1/Page 4 ofFilip M, Bader M (2009) Overview on 5HT receptors and their role in physiology and pathology of your central nervous system. Pharmacol Rep 61:76177 Greek AR (2006) Neuropharmacology of 5hydroxytryptamine. Br J Pharmacol 147(Supple 1):14552 Hammon J, Hoyer D (2008) Molecular biology of 5HT receptors.Buy1-(Quinolin-2-yl)ethanone Behav Brain Res 195:19813 Kara SL (2010) Pediatric headache.PMID:24293312 Pediatr Neurol 17:22429 Lewis D, Ashwal S, Hershey A et al (2004) Practice parameter: pharmacological remedy of migraine headache in young children and adolescents: report with the Americcan academy of neurology good quality requirements subcommittee plus the practice committee from the child neurology society. Neurology 63:2215224 Mathew NT (2001) Pathophysiology, epidemiology, and effect of migraine. Clin Comerstone 4:17 Olesen J, Bousser MG, Diener HC et al (2004) Headache Classification Committee on the International Headache Society The International Classification of Headache Issues, 2nd edn. Cephalalgia 24(1):160 Ollat H (1992) Serotonin agonists and antagonists in migraine. Pathol Biol 40:38996 Pascual J (2012) Chronic migraine: treatment. Rev Neurol 54(Suppl two):318 Rao BS, Das DG, Taraknath VR, Sarma Y (2000) A double blind controlled study of propranolol and cyproheptadine in migraine prophylaxis. Neurol India 48:22326 Silberstein SD (2004) Migraine pathophysiology and its clinical implications. Cephalalgia 24:1045048 Tfelthansen Pc (2013) Evidencebased guideline update: Pharmacologic remedy for episodic migraine prevention in adults: Report with the high quality requirements subcommittee of the American Academy of Neurology and American Headache Society. Neurology 80:86970 Villalon CM, Olsen J (2009) The function of CGRP within the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute.
