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While heart is a special and dynamic organ functioning ceaselessly all through life, it is very vulnerable to illness pathology. Cardiovascular illness (CVD) is definitely the top reason for morbidity and mortality across the planet. Even though majority of analysis emphasize on CVD, significantly less consideration has been paid for the sophisticated regulatory mechanisms and microenvironment supplied by cardiac matrix. Cardiac matrix is important for synchronized beating of cardiomyocytes that sustain the untiring contraction-relaxation cycle from the heart. Not too long ago, it was discovered that elasticity of matrix plays a pivotal function in lineage specification [1] and self-renewal [2] of stem cells. The heart has self-renewing capacity due to endogenous ca.